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Ashwagandha

Ashwagandha is a revered Ayurvedic medicinal herb, which has come to be further studied by scientists today. It is revered for its adaptogenic properties, and has been used for millenia to relieve stress, fatigue, and insomnia. A rich source of phytochemicals, Ashwagandha has been proven to support the body and aid recovery, while also acting synergistically with coffee!

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Quercetin

Quercetin is a naturally occurring polyphenol and is a known anti-inflammatory and anti-oxidant. On top of its proven effects in mitigating cellular damage, scientists have recently found that quercetin is able to directly remove harmful older cells before they accumulate in the body. This makes quercetin a powerful senolytic and a key part of UDA's formula!

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Alpha-ketoglutarate

AKG is produced by the body during metabolism, but as we age, scientists have shown that AKG levels decline, and this is linked with functional decline! AKG has been studied by longevity scientists, who have shown that supplementing the AKG that is lost with age can reverse biological ageing by 8 years or more, as measured by the epigenetic clocks. UDA is packed with AKG to combat the loss of this key part of cellular energy levels and metabolism with age!

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L-theanine

L-theanine in an amino acid which has been used by many to enhance the experience of drinking coffee. Not only does it make the experience smoother and richer, but brain-scan studies have shown that L-theanine on its own can enhance focus, attention, and clarity of thought!

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Curcumin

Curcumin, found in the yellow turmeric spice, is a powerful anti-oxidant which reduces cellular damage. It also enhances immune system function, which is otherwise known to decline with age.

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NMN

Nicotinamide mononucleotide is one of the most promising longevity molecules right now. NMN directly increases levels of a key signalling molecule called NAD, which declines with age and is linked to loss of DNA repair and maintenance ability. NMN has been studied by scientists for its ability to reverse several key components of the ageing process!

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Vitamin D

Vitamin D is made naturally in our skin upon exposure to sunlight, but scientists have shown that a large percentage of adults are deficient! Vitamin D is not only involved in promoting healthy skeletal ageing, but it is additionally an incredibly important in signalling molecule which interacts with genes known to be associated with healthy longevity!

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Barista-style Coffee

There's a reason we chose coffee as the ideal delivery vehicle for UDA's longevity-promoting goodness! Aside from getting us through the day, coffee is actually extremely well studied for its longevity benefits. Scientists have shown that drinking 2 cups of coffee a day lowers the overall risk of stroke, Alzheimer's Disease, and heart attacks. All of that, and it tastes great!

Studies

Ashwagandha

Chandrasekhar, K., Kapoor, J. and Anishetty, S. (2012) ‘A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults’, Indian Journal of Psychological Medicine, 34(3), pp. 255–262. Available at: https://doi.org/10.4103/0253-7176.106022.

Widodo, N. et al. (2009) ‘Deceleration of Senescence in Normal Human Fibroblasts by Withanone Extracted From Ashwagandha Leaves’, The Journals of Gerontology: Series A, 64A(10), pp. 1031–1038. Available at: https://doi.org/10.1093/gerona/glp088.

Langade, D. et al. (2019) ‘Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study’, Cureus, 11(9), p. e5797. Available at: https://doi.org/10.7759/cureus.5797.

Sanjeev K. Gupta, Anita Dua and Bhupinder P. S. Vohra (2003) ‘Withania somnifera (ASHWAGANDHA) ATTENUATES ANTIOXIDANT DEFENSE IN AGED SPINAL CORD AND INHIBITS COPPER INDUCED LIPID PEROXIDATION AND PROTEIN OXIDATIVE MODIFICATIONS’, Drug Metabolism and Drug Interactions, 19(3), pp. 211–222. Available at: https://doi.org/10.1515/DMDI.2003.19.3.211.

Jagota, A. and Kowshik, K. (2017) ‘Therapeutic Effects of Ashwagandha in Brain Aging and Clock Dysfunction’, in S.C. Kaul and R. Wadhwa (eds) Science of Ashwagandha: Preventive and Therapeutic Potentials. Cham: Springer International Publishing, pp. 437–456. Available at: https://doi.org/10.1007/978-3-319-59192-6_21.

Quercetin

Boots, A.W. et al. (2011) ‘Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis’, Clinical Nutrition (Edinburgh, Scotland), 30(4), pp. 506–512. Available at: https://doi.org/10.1016/j.clnu.2011.01.010.

Xu, M. et al. (2018) ‘Senolytics improve physical function and increase lifespan in old age’, Nature Medicine, 24(8), pp. 1246–1256. Available at: https://doi.org/10.1038/s41591-018-0092-9.

Singh, A., Naidu, P.S. and Kulkarni, S.K. (2003) ‘Reversal of Aging and Chronic Ethanol-induced Cognitive Dysfunction by Quercetin a Bioflavonoid’, Free Radical Research, 37(11), pp. 1245–1252. Available at: https://doi.org/10.1080/10715760310001616014.

Hung, C.-H. et al. (2015) ‘Quercetin is a potent anti-atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation’, Molecular Nutrition & Food Research, 59(10), pp. 1905–1917. Available at: https://doi.org/10.1002/mnfr.201500144.

Casella, M.L. et al. (2014) ‘Quercetin prevents liver carcinogenesis by inducing cell cycle arrest, decreasing cell proliferation and enhancing apoptosis’, Molecular Nutrition & Food Research, 58(2), pp. 289–300. Available at: https://doi.org/10.1002/mnfr.201300362.

Zoico, E. et al. (2021) ‘Senolytic effects of quercetin in an in vitro model of pre-adipocytes and adipocytes induced senescence’, Scientific Reports, 11(1), p. 23237. Available at: https://doi.org/10.1038/s41598-021-02544-0.

Alpha ketoglutarate

Tian, Q. et al. (2021) ‘Dietary Alpha-Ketoglutarate Promotes Epithelial Metabolic Transition and Protects against DSS-Induced Colitis’, Molecular Nutrition & Food Research, 65(7), p. 2000936. Available at: https://doi.org/10.1002/mnfr.202000936.

Asadi Shahmirzadi, Azar et al. (2020) ‘Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice’, Cell Metabolism, 32(3), pp. 447-456.e6. Available at: https://doi.org/10.1016/j.cmet.2020.08.004.

Niemiec, T. et al. (2011) ‘Alpha-ketoglutarate stabilizes redox homeostasis and improves arterial elasticity in aged mice’, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 62, pp. 37–43.

Żurek, A. et al. (2019) ‘Alpha ketoglutarate exerts a pro-osteogenic effect in osteoblast cell lines through activation of JNK and mTOR/S6K1/S6 signaling pathways’, Toxicology and Applied Pharmacology, 374, pp. 53–64. Available at: https://doi.org/10.1016/j.taap.2019.04.024.

Chin, R.M. et al. (2014) ‘The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR’, Nature, 510(7505), pp. 397–401. Available at: https://doi.org/10.1038/nature13264.

Nicotinamide Mononucleotide

Kiss, T. et al. (2020) ‘Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects’, GeroScience, 42(2), pp. 527–546. Available at: https://doi.org/10.1007/s11357-020-00165-5.

Yoshino, J., Baur, J.A. and Imai, S. (2018) ‘NAD+ intermediates: The biology and therapeutic potential of NMN and NR’, Cell metabolism, 27(3), pp. 513–528. Available at: https://doi.org/10.1016/j.cmet.2017.11.002.

Huang, H. (2022) ‘A Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of Uthever (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older Adults’, Frontiers in Aging, 3. Available at: https://www.frontiersin.org/articles/10.3389/fragi.2022.851698 (Accessed: 5 September 2022).

Mills, K.F. et al. (2016) ‘Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice’, Cell Metabolism, 24(6), pp. 795–806. Available at: https://doi.org/10.1016/j.cmet.2016.09.013.

Irie, J. et al. (2020) ‘Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men’, Endocrine Journal, 67(2), pp. 153–160. Available at: https://doi.org/10.1507/endocrj.EJ19-0313.

Vitamin D

Li, W. et al. (2021) ‘Study of calcitriol anti-aging effects on human natural killer cells in vitro’, Bioengineered, 12(1), pp. 6844–6854. Available at: https://doi.org/10.1080/21655979.2021.1972076.

de Jongh, R.T., van Schoor, N.M. and Lips, P. (2017) ‘Changes in vitamin D endocrinology during aging in adults’, Molecular and Cellular Endocrinology, 453, pp. 144–150. Available at: https://doi.org/10.1016/j.mce.2017.06.005.

Gómez-Oliva, R. et al. (2020) ‘Vitamin D deficiency as a potential risk factor for accelerated aging, impaired hippocampal neurogenesis and cognitive decline: a role for Wnt/β-catenin signaling’, Aging, 12(13), pp. 13824–13844. Available at: https://doi.org/10.18632/aging.103510.

Ong, L.T.C., Booth, D.R. and Parnell, G.P. (2020) ‘Vitamin D and its Effects on DNA Methylation in Development, Aging, and Disease’, Molecular Nutrition & Food Research, 64(23), p. 2000437. Available at: https://doi.org/10.1002/mnfr.202000437.

L-theanine

Yuan, S. et al. (2021) ‘Effects of single-dose L-theanine on motor cortex excitability’, Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology, 132(9), pp. 2062–2064. Available at: https://doi.org/10.1016/j.clinph.2021.07.003.

Zeng, L. et al. (2020) ‘l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation’, Experimental Gerontology, 131, p. 110823. Available at: https://doi.org/10.1016/j.exger.2019.110823.

Miodownik, C. et al. (2011) ‘Serum levels of brain-derived neurotrophic factor and cortisol to sulfate of dehydroepiandrosterone molar ratio associated with clinical response to L-theanine as augmentation of antipsychotic therapy in schizophrenia and schizoaffective disorder patients’, Clinical Neuropharmacology, 34(4), pp. 155–160. Available at: https://doi.org/10.1097/WNF.0b013e318220d8c6.

Zarse, K., Jabin, S. and Ristow, M. (2012) ‘l-Theanine extends lifespan of adult Caenorhabditis elegans’, European Journal of Nutrition, 51(6), pp. 765–768. Available at: https://doi.org/10.1007/s00394-012-0341-5.

Zeng, L. et al. (2021) ‘l-Theanine Ameliorates d-Galactose-Induced Brain Damage in Rats via Inhibiting AGE Formation and Regulating Sirtuin1 and BDNF Signaling Pathways’, Oxidative Medicine and Cellular Longevity, 2021, p. 8850112. Available at: https://doi.org/10.1155/2021/8850112.

Liu, K. et al. (2022) ‘l -Theanine mediates the p38MAPK signaling pathway to alleviate heat-induced oxidative stress and inflammation in mice’, Food & Function, 13(4), pp. 2120–2130. Available at: https://doi.org/10.1039/D1FO03077A.

Curcumin

Small, G.W. et al. (2018) ‘Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial’, The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry, 26(3), pp. 266–277. Available at: https://doi.org/10.1016/j.jagp.2017.10.010.

Eaton, J.E. et al. (2019) ‘Efficacy and safety of curcumin in primary sclerosing cholangitis: an open label pilot study’, Scandinavian Journal of Gastroenterology, 54(5), pp. 633–639. Available at: https://doi.org/10.1080/00365521.2019.1611917.

Wynn, J.K. et al. (2018) ‘The effects of curcumin on brain-derived neurotrophic factor and cognition in schizophrenia: A randomized controlled study’, Schizophrenia Research, 195, pp. 572–573. Available at: https://doi.org/10.1016/j.schres.2017.09.046.

Petracca, M. et al. (2021) ‘ProspeCtive study to evaluate efficacy, safety and tOlerability of dietary supplemeNT of Curcumin (BCM95) in subjects with Active relapsing MultIple Sclerosis treated with subcutaNeous Interferon beta 1a 44 mcg TIW (CONTAIN): A randomized, controlled trial’, Multiple Sclerosis and Related Disorders, 56, p. 103274. Available at: https://doi.org/10.1016/j.msard.2021.103274.

Rezende, C. et al. (2022) ‘Turmeric root extract supplementation improves pre-frontal cortex oxygenation and blood volume in older males and females: a randomised cross-over, placebo-controlled study’, International Journal of Food Sciences and Nutrition, 73(2), pp. 274–283. Available at: https://doi.org/10.1080/09637486.2021.1972411.

Zia, A. et al. (2021) ‘The role of curcumin in aging and senescence: Molecular mechanisms’, Biomedicine & Pharmacotherapy, 134, p. 111119. Available at: https://doi.org/10.1016/j.biopha.2020.111119.

Li, W. et al. (2019) ‘The curcumin analog EF24 is a novel senolytic agent’, Aging (Albany NY), 11(2), pp. 771–782. Available at: https://doi.org/10.18632/aging.101787.

Caffeine

van Gelder, B.M. et al. (2007) ‘Coffee consumption is inversely associated with cognitive decline in elderly European men: the FINE Study’, European Journal of Clinical Nutrition, 61(2), pp. 226–232. Available at: https://doi.org/10.1038/sj.ejcn.1602495.

Poole, R. et al. (2017) ‘Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes’, BMJ, 359, p. j5024. Available at: https://doi.org/10.1136/bmj.j5024.

Postuma, R.B. et al. (2017) ‘Caffeine as symptomatic treatment for Parkinson disease (Café-PD): A randomized trial’, Neurology, 89(17), pp. 1795–1803. Available at: https://doi.org/10.1212/WNL.0000000000004568.

Tao, L. et al. (2021) ‘Caffeine promotes the expression of telomerase reverse transcriptase to regulate cellular senescence and aging’, Food & Function, 12(7), pp. 2914–2924. Available at: https://doi.org/10.1039/D0FO03246H.

Garcez, M.L. et al. (2019) ‘Caffeine Neuroprotection Decreases A2A Adenosine Receptor Content in Aged Mice’, Neurochemical Research, 44(4), pp. 787–795. Available at: https://doi.org/10.1007/s11064-018-02710-3.